grim promotes programmed cell death of Drosophila microchaete glial cells

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grim promotes programmed cell death of Drosophila microchaete glial cells

The Inhibitor of apoptosis (IAP) antagonists Reaper (Rpr), Grim and Hid are central regulators of developmental apoptosis in Drosophila. Ectopic expression of each is sufficient to trigger apoptosis, and hid and rpr have been shown to be important for programmed cell death (PCD). To investigate the role for grim in PCD, a grim null mutant was generated. grim was not a key proapoptotic gene for ...

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Neuronal programmed cell death induces glial cell division in the adult Drosophila brain.

Although mechanisms that lead to programmed cell death (PCD) in neurons have been analysed extensively, little is known about how surrounding cells coordinate with it. Here we show that neuronal PCD in the Drosophila brain induces glial cell division. We identified PCD in neurons and cell division in glia occurring in a consistent spatiotemporal manner in adult flies shortly after eclosion. Gli...

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Drosophila sickle Is a Novel grim-reaper Cell Death Activator

The Drosophila genes reaper, head involution defective (hid), and grim all reside at 75C on chromosome three and encode related proteins that have crucial functions in programmed cell death (reviewed in ). In this report, we describe a novel grim-reaper gene, termed sickle, that resides adjacent to reaper. The sickle gene, like reaper and grim, encodes a small protein which contains an RHG moti...

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grim, a novel cell death gene in Drosophila.

A genomic interval at 75C1,2 is required for programmed cell death in Drosophila. We identified a new activator of apoptosis, grim, which maps between two previously identified cell death genes in this region reaper (rpr) and head involution defective (hid). Expression of grim RNA coincided with the onset of programmed cell death at all stages of embryonic development, whereas ectopic induction...

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Programmed cell death during Drosophila embryogenesis.

The deliberate and orderly removal of cells by programmed cell death is a common phenomenon during the development of metazoan animals. We have examined the distribution and ultrastructural appearance of cell deaths that occur during embryogenesis in Drosophila melanogaster. A large number of cells die during embryonic development in Drosophila. These cells display ultrastructural features that...

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ژورنال

عنوان ژورنال: Mechanisms of Development

سال: 2010

ISSN: 0925-4773

DOI: 10.1016/j.mod.2010.06.001